A locus for complicated hereditary spastic paraplegia maps to chromosome 1q24-q32.
other · Level V
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Abstract
We updated the clinical features of a consanguineous Arab Israeli family, in which four of seven children were affected by spastic paraplegia complicated by skin pigmentary abnormalities. A genomewide linkage screen performed for the family identified a new locus (SPG23) for this form of hereditary spastic paraplegia, in an approximately 25cM region of chromosome 1q24-q32, with a peak logarithm of odds score of 3.05.
Medical subject headings
- Chromosomes, Human, Pair 1
- Genetic Markers
- Skin Diseases, Genetic
- Spastic Paraplegia, Hereditary