Pyoderma gangrenosum, polycythemia rubra vera, and the development of leukemia.

Ho, K K; Otridge, B W; Vandenberg, E; Powell, F C · J Am Acad Dermatol · 1992

case_report · Level V

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Abstract

A patient with long-standing, well-controlled polycythemia rubra vera developed recurrent episodes of bullous pyoderma gangrenosum followed by the transformation of his hematologic disease into a rapidly progressive acute myeloid leukemia. This case, together with previously described patients, indicates that the appearance of bullous pyoderma gangrenosum in a patient with polycythemia rubra vera is often of ominous prognostic significance.

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