Chronic neuropathy with IgM anti-ganglioside antibodies: lack of long term response to rituximab.
case_series · Level IV
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- Record sourced from PubMed, PMID 14694058.
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Abstract
Two patients with chronic motor neuropathy, high antiganglioside antibody (AGA) titers, and a declining response to IV immunoglobulins were treated with rituximab at a standard dose. The drug was well tolerated and effectively eliminated peripheral B cells (CD20+), but AGA titers continued significantly high. No clinical improvement was detected during the 1-year follow-up.
Medical subject headings
- Antibodies, Monoclonal
- Autoimmune Diseases of the Nervous System
- Gangliosides
- Immunoglobulin M