The enemy at the gates. Ca2+ entry through TRPM7 channels and anoxic neuronal death.
basic_science · Level V
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Abstract
In brain ischemia, gating of postsynaptic glutamate receptors is thought to initiate Ca2+ overload leading to excitotoxic neuronal death. In this issue, Aarts and colleagues describe a novel mechanism, whereby gating of TRPM7, a Ca2+-permeable nonselective cation channel, mediates Ca2+ overload and demise of anoxic neurons.
Medical subject headings
- Calcium
- Hypoxia-Ischemia, Brain
- Ion Channels
- Membrane Proteins
- Nerve Degeneration
- Protein Kinases