VEGF: a critical player in neurodegeneration.
review · Level V
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- Record sourced from PubMed, PMID 14702101.
- Also identified by PMC identifier 300888.
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Abstract
VEGF is a prototype angiogenic factor, but recent evidence indicates that this growth factor also has direct effects on neural cells. Abnormal regulation of VEGF expression has now been implicated in several neurodegenerative disorders, including motoneuron degeneration. This has stimulated an increasing interest in assessing the therapeutic potential of VEGF as a neuroprotective agent for such neurodegenerative disorders.
Medical subject headings
- Nerve Degeneration
- Vascular Endothelial Growth Factor A