The progression of maternal RSV antibodies in the offspring.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 14709507.
- Also identified by PMC identifier 1755925.
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Abstract
The concentrations of maternal anti-RSV IgG antibodies were followed in 49 healthy newborns over the first six months of life. At birth, 41 mothers (83%) tested positive for anti-RSV IgG and all of their babies carried maternal anti-RSV IgG. Anti-RSV IgG positivity dropped to 73% at 1 month, 6% at 3 months, and 2% at 6 months. Between 3 and 6 months, 8% did acquire RSV infection, half of them as acute bronchiolitis and half as non-specific respiratory infection. All of the patients who acquired clinical RSV disease had an antibody concentration of <20 RU/ml which may be the cut off value for protection.
Medical subject headings
- Antibodies, Anti-Idiotypic
- Antibodies, Viral
- Immunity, Maternally-Acquired
- Pregnancy Complications, Infectious
- Respiratory Syncytial Virus Infections
- Respiratory Syncytial Viruses