Instructive role of Wnt/beta-catenin in sensory fate specification in neural crest stem cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 14716020.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Wnt signaling has recently emerged as a key factor in controlling stem cell expansion. In contrast, we show here that Wnt/beta-catenin signal activation in emigrating neural crest stem cells (NCSCs) has little effect on the population size and instead regulates fate decisions. Sustained beta-catenin activity in neural crest cells promotes the formation of sensory neural cells in vivo at the expense of virtually all other neural crest derivatives. Moreover, Wnt1 is able to instruct early NCSCs (eNCSCs) to adopt a sensory neuronal fate in a beta-catenin-dependent manner. Thus, the role of Wnt/beta-catenin in stem cells is cell-type dependent.
Medical subject headings
- Cytoskeletal Proteins
- Multipotent Stem Cells
- Neural Crest
- Neurons, Afferent
- Proto-Oncogene Proteins
- Signal Transduction
- Trans-Activators
- Zebrafish Proteins