Alpha-synuclein haplotypes implicated in risk of Parkinson's disease.
case_control · Level III
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Abstract
The authors examined four- and six-loci haplotype constructs (from five single nucleotide polymorphisms and three microsatellite regions) of the alpha-synuclein gene in patients with Parkinson's disease (PD) and controls in an ethnic Chinese population. Logistic regression analysis demonstrated an association of NACP-Rep1 (p = 0.002) and L478 (p < 0.0001) with risk of PD after correction for the effects of age, sex, and the other polymorphic loci. Specific four-loci and six-loci haplotypes were significantly associated with an increased or decreased risk of PD.
Medical subject headings
- Genetic Predisposition to Disease
- Haplotypes
- Nerve Tissue Proteins
- Parkinson Disease
- Polymorphism, Genetic