Hypocretin-1 CSF levels in anti-Ma2 associated encephalitis.
case_series · Level IV
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- Record sourced from PubMed, PMID 14718718.
- Also identified by PMC identifier 2574537.
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Abstract
Idiopathic narcolepsy is associated with deficient hypocretin transmission. Narcoleptic symptoms have recently been described in paraneoplastic encephalitis with anti-Ma2 antibodies. The authors measured CSF hypocretin-1 levels in six patients with anti-Ma2 encephalitis, and screened for anti-Ma antibodies in patients with idiopathic narcolepsy. Anti-Ma autoantibodies were not detected in patients with idiopathic narcolepsy. Four patients with anti-Ma2 encephalitis had excessive daytime sleepiness; hypocretin-1 was not detectable in their cerebrospinal fluid, suggesting an immune-mediated hypocretin dysfunction.
Medical subject headings
- Autoimmune Diseases of the Nervous System
- Carrier Proteins
- Encephalitis
- Intracellular Signaling Peptides and Proteins
- Neuropeptides
- Paraneoplastic Syndromes, Nervous System
- Proteins