Telomeres, stem cells, senescence, and cancer.
review · Level V
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- Record sourced from PubMed, PMID 14722605.
- Also identified by PMC identifier 311439.
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Abstract
Mammalian aging occurs in part because of a decline in the restorative capacity of tissue stem cells. These self-renewing cells are rendered malignant by a small number of oncogenic mutations, and overlapping tumor suppressor mechanisms (e.g., p16(INK4a)-Rb, ARF-p53, and the telomere) have evolved to ward against this possibility. These beneficial antitumor pathways, however, appear also to limit the stem cell life span, thereby contributing to aging.
Medical subject headings
- Apoptosis
- Cellular Senescence
- Neoplasms
- Telomere