Unraveling V(D)J recombination; insights into gene regulation.
review · Level V
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- Record sourced from PubMed, PMID 14744439.
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Abstract
V(D)J recombination assembles antigen receptor genes from component gene segments. We review findings that have shaped our current understanding of this remarkable mechanism, with a focus on two major reports--the first detailed comparison of germline and rearranged antigen receptor loci and the discovery of the recombination activating gene-1.
Medical subject headings
- Gene Expression Regulation
- Genes, RAG-1
- VDJ Recombinases