Valproic acid has no effect on pain in polyneuropathy: a randomized, controlled trial.
rct · Level II
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- Record sourced from PubMed, PMID 14745070.
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Abstract
The aim of this randomized, double-blind, placebo-controlled cross-over study was to test whether valproic acid relieves painful polyneuropathy. Thirty-one patients completed two treatment phases of 4 weeks' duration with valproic acid (1,500 mg daily) and placebo. There was no significant difference between valproic acid and placebo in the rating of total pain (median, 5 in the valproic acid period vs 6 in the placebo period; p = 0.24) or in individual pain ratings.
Medical subject headings
- Neuralgia
- Polyneuropathies
- Valproic Acid