Central role of the P2Y12 receptor in platelet activation.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 14755328.
- Also identified by PMC identifier 324551.
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Abstract
Platelet activation occurs in response to vessel injury and is important for the arrest of bleeding. Platelet activation during disease states leads to vascular occlusion and ischemic damage. The P2Y(12) receptor, activated by ADP, plays a central role in platelet activation and is the target of P2Y(12) receptor antagonists that have proven therapeutic value.
Medical subject headings
- Blood Platelets
- Membrane Proteins
- Platelet Activation
- Receptors, Purinergic P2