Achieving antigen-specific immune regulation.
review · Level V
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- Record sourced from PubMed, PMID 14755329.
- Also identified by PMC identifier 324549.
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Abstract
A study in this issue of the JCI shows that in response to autoantigens consisting of peptides from normal proteins, patients with diabetes mount a T cell response characterized by production of IFN-gamma (see the related article beginning on page 451). However, in response to these same antigens, T cells from normal control subjects produce IL-10. The antigen-specific response characterized by release of a regulatory cytokine suggests a mechanism for the control of autoimmunity that is initiated at the time of antigen presentation.
Medical subject headings
- Antigens
- Immune System