gp41: HIV's shy protein.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 14760422.
- Also identified by PMC identifier 7095992.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The first X-ray crystal structures of gp41, the protein that mediates fusion of HIV-1 to target cells, were solved in the mid-1990s. The structures provide a foundation for understanding viral entry and the mechanism of action of compounds that block fusion. The first fusion inhibitor has recently entered the clinic, and the hope is that more potent and broadly active compounds, based on molecular design, will follow.
Medical subject headings
- HIV Envelope Protein gp41
- HIV-1
- Protein Conformation