GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells.
basic_science · Level V
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- Record sourced from PubMed, PMID 14769923.
- Also identified by PMC identifier 357040.
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Abstract
T helper type 2 (Th2) cells secrete IL-4, IL-5, IL-10, and IL-13 and mediate allergic and asthmatic disease. GATA-3 is a Th2-specific transcription factor that appears in overexpression studies and transgenic systems to function as a Th2 lineage determinant. Because GATA-3 is also crucial for development of the T lineage and throughout thymic development, direct demonstration that GATA-3 is required for Th2 development by targeted deletion has been lacking. Using a conditional knockout approach, we found that GATA-3 is required for optimal Th2 cytokine production in vitro and in vivo. Our data also show that GATA-3 expression must be sustained to maintain the Th2 phenotype.
Medical subject headings
- DNA-Binding Proteins
- Th2 Cells
- Trans-Activators