Structural basis of transcription: separation of RNA from DNA by RNA polymerase II.
basic_science · Level V
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Abstract
The structure of an RNA polymerase II-transcribing complex has been determined in the posttranslocation state, with a vacancy at the growing end of the RNA-DNA hybrid helix. At the opposite end of the hybrid helix, the RNA separates from the template DNA. This separation of nucleic acid strands is brought about by interaction with a set of proteins loops in a strand/loop network. Formation of the network must occur in the transition from abortive initiation to promoter escape.
Medical subject headings
- DNA, Single-Stranded
- RNA Polymerase II
- RNA, Complementary
- Transcription, Genetic