Human African trypanosomiasis of the CNS: current issues and challenges.
review · Level V
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- Record sourced from PubMed, PMID 14966556.
- Also identified by PMC identifier 338269.
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Abstract
Human African trypanosomiasis (HAT), also known as sleeping sickness, is a major cause of mortality and morbidity in sub-Saharan Africa. Current therapy with melarsoprol for CNS HAT has unacceptable side-effects with an overall mortality of 5%. This review discusses the issues of diagnosis and staging of CNS disease, its neuropathogenesis, and the possibility of new therapies for treating late-stage disease.
Medical subject headings
- Central Nervous System Protozoal Infections
- Trypanosomiasis, African