HDL action on the vascular wall: is the answer NO?

Shaul, Philip W; Mineo, Chieko · J Clin Invest · 2004

editorial · Level V

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Abstract

Circulating levels of HDL cholesterol are inversely related to the risk of atherosclerosis, and therapeutic increases in HDL reduce the incidence of cardiovascular events. A new study shows that HDL-associated lysophospholipids stimulate the production of the potent antiatherogenic signaling molecule NO by the vascular endothelium.

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