Pathology: cancer cells compress intratumour vessels.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 14973470.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The delivery of therapeutic drugs to solid tumours may be impaired by structural and functional abnormalities in blood and lymphatic vessels. Here we provide evidence that proliferating cancer cells cause intratumour vessels to compress and collapse. By reducing this compressive mechanical force and opening vessels, cytotoxic cancer treatments have the potential to increase blood perfusion, thereby improving drug delivery.
Medical subject headings
- Diphtheria Toxin
- Neoplasms
- Reperfusion