Alpha1 antitrypsin and the prevalence and severity of asthma.
cross_sectional · Level IV
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- Record sourced from PubMed, PMID 14977698.
- Also identified by PMC identifier 1719844.
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Abstract
In a random sample of children (aged 9-11 years; n = 5629), who were studied according to the ISAAC phase II protocol, heterozygosity of the alpha1 antitrypsin (alpha1-AT) Pi genotypes MS or MZ, or low alpha1-AT plasma levels, were not associated with an increased risk of developing asthma. Asthmatics with low levels of alpha1-AT were particularly prone to develop airway hyperresponsiveness and reduced lung function.
Medical subject headings
- Asthma
- alpha 1-Antitrypsin