Control of pancreas and liver gene expression by HNF transcription factors.
basic_science · Level V
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- Record sourced from PubMed, PMID 14988562.
- Also identified by PMC identifier 3012624.
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Abstract
The transcriptional regulatory networks that specify and maintain human tissue diversity are largely uncharted. To gain insight into this circuitry, we used chromatin immunoprecipitation combined with promoter microarrays to identify systematically the genes occupied by the transcriptional regulators HNF1alpha, HNF4alpha, and HNF6, together with RNA polymerase II, in human liver and pancreatic islets. We identified tissue-specific regulatory circuits formed by HNF1alpha, HNF4alpha, and HNF6 with other transcription factors, revealing how these factors function as master regulators of hepatocyte and islet transcription. Our results suggest how misregulation of HNF4alpha can contribute to type 2 diabetes.
Medical subject headings
- DNA-Binding Proteins
- Gene Expression Regulation
- Hepatocytes
- Homeodomain Proteins
- Islets of Langerhans
- Nuclear Proteins
- Phosphoproteins
- Trans-Activators
- Transcription Factors