Effect of ibuprofen on bilirubin-albumin binding.
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- Record sourced from PubMed, PMID 15001951.
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Abstract
Ibuprofen is used for closing the ductus arteriosus in premature newborn infants. Ibuprofen interferes with bilirubin-albumin binding and increases the unbound bilirubin in pooled newborn plasma to levels similar to those produced by sulfisoxazole, a drug that causes kernicterus in premature newborn infants.
Medical subject headings
- Albumins
- Anti-Inflammatory Agents, Non-Steroidal
- Bilirubin
- Ibuprofen
- Jaundice, Neonatal