The development of hepatocellular carcinoma among prospectively followed children with chronic hepatitis B virus infection.
prospective_cohort · Level II
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Abstract
We prospectively followed 426 children with chronic hepatitis B virus infection. During 6250 person-years, 2 boys developed hepatocellular carcinoma, with an incidence of 32 per 100,000 person-years. Both had e antigen seroconversion in early childhood and cirrhosis. Early e antigen seroconversion and/or cirrhosis may be risk factors for hepatocellular carcinoma.
Medical subject headings
- Carcinoma, Hepatocellular
- Hepatitis B, Chronic
- Liver Neoplasms