Converting a motor to an anchor.
basic_science · Level V
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- Record sourced from PubMed, PMID 15006345.
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Abstract
Myosin VI can move along actin filaments to serve as a transport motor. It is also thought to anchor vesicles or proteins to actin. How these two diverse activities, which require very different modes of interaction with actin, are mediated is not understood. Using single molecule observations, Altman et al. (2004 [this issue of Cell]) demonstrate that load applied to myosin VI can convert this motor from a transporter to an anchor.
Medical subject headings
- Molecular Motor Proteins
- Myosin Heavy Chains