Anti-GQ1b antibody as a factor predictive of mechanical ventilation in Guillain-Barré syndrome.
retrospective_cohort · Level III
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Abstract
Compared with 87 unventilated patients with Guillain-Barré syndrome (GBS), 44 ventilated patients with GBS more frequently had multiple cranial nerve involvement (91 vs 50%; p < 0.001) and IgG anti-GQ1b antibody (27 vs 8%; p = 0.006). In GBS patients without ophthalmoparesis, the presence of IgG anti-GQ1b antibody was associated with respiratory failure (12 [3/25] vs 0% [0/67]; p = 0.04). The presence of the antibody may be a factor predictive of respiratory failure in GBS.
Medical subject headings
- Antibodies, Anti-Idiotypic
- Gangliosides
- Guillain-Barre Syndrome
- Respiration, Artificial
- Respiratory Insufficiency