Active-site dynamics in RNA polymerases.
basic_science · Level V
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Abstract
New crystal structures of transcription complexes formed by bacteriophage T7 RNA polymerase reveal a nucleotide-addition cycle driven by active-site conformational changes similar to those observed in DNA polymerases, and suggest provocative hypotheses for the more complex multisubunit RNA polymerases of free-living organisms.
Medical subject headings
- DNA-Directed RNA Polymerases
- Gene Expression Regulation, Viral
- RNA, Messenger