Influence of the concentrations of hyaluronic acid on the properties and biocompatibility of Cs-Gel-HA membranes.
basic_science · Level V
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Abstract
The object of this study was to investigate the relationship between the concentrations of HA solutions and the physicochemical properties and the biocompatibility of Cs-Gel-HA membranes. The addition of different concentrations of HA not only improved the wettability significantly and extended the degradation time of Cs-Gel-HA membranes, but also changed their mechanical properties. The concentration of HA had a significant influence on the biocompatibility of Cs-Gel-HA membranes. Results demonstrated that it was only the concentrations of HA in a certain range (0.01-0.1%), that could promote the cell adhesion, migration and proliferation, while the concentration of HA was above 0.1% it would either reduce or even inhibit these behaviors.
Medical subject headings
- Cesium
- Durapatite
- Fibroblasts
- Hyaluronic Acid
- Membranes, Artificial