Human papillomavirus (HPV) origin-binding protein associates with mitotic spindles to enable viral DNA partitioning.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 15020762.
- Also identified by PMC identifier 384690.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Human papillomaviruses (HPVs) establish long-term infections in patients. The mechanism for extrachromosomal HPV DNA persistence in cycling cells is unknown. We show that HPV origin-containing plasmids partition as minichromosomes, attributable to an association of the viral origin recognition protein E2 with mitotic spindles. alpha-, beta-, and gamma-tubulins were pulled down with a tagged E2. The N-terminal transacting and C-terminal protein dimerization/DNA binding domains independently associated with the spindles. We suggest that this E2 property enables these viruses to establish persistence. Its implication for HPV oncogenesis is presented.
Medical subject headings
- DNA, Viral
- DNA-Binding Proteins
- Papillomaviridae
- Spindle Apparatus
- Viral Proteins