Brain tissue loss occurs after suppression of enhancement in patients with multiple sclerosis treated with autologous haematopoietic stem cell transplantation.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 15026517.
- Also identified by PMC identifier 1738998.
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Abstract
To assess whether brain tissue loss occurs after profound and sustained suppression of magnetic resonance imaging (MRI) enhancement, we measured brain volume changes from 10 patients with rapidly evolving secondary progressive multiple sclerosis (MS) treated with autologous haematopoietic stem cell transplantation and followed up for 24 months. An average yearly decrease of brain volume of about 1.9% was observed despite only five enhancing lesions seen on triple dose follow up scans of two patients. This indicates that, in MS, progressive loss of tissue can occur independently of concomitant MRI-visible inflammation.
Medical subject headings
- Brain
- Hematopoietic Stem Cell Transplantation
- Image Enhancement
- Image Processing, Computer-Assisted
- Magnetic Resonance Imaging
- Multiple Sclerosis, Chronic Progressive