Prognostic value of the MIB-1 labeling index for central neurocytomas.
meta_analysis · Level I
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Abstract
Although central neurocytomas are generally described as benign CNS lesions, malignant behavior including craniospinal dissemination and tumor-related death may occur. This meta-analysis was performed to investigate the prognostic value of the MIB-1 labeling index. Data were obtained not from the literature alone but also from contact with the authors. The data suggested an MIB-1 index score of >3% to be associated with a worse prognosis for local control (p < 0.0001) and survival (p = 0.0004).
Medical subject headings
- Antibodies, Antinuclear
- Antibodies, Monoclonal
- Central Nervous System Neoplasms
- Ki-67 Antigen
- Neurocytoma