Pilot trial of albuterol in Duchenne and Becker muscular dystrophy.
rct · Level II
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- Record sourced from PubMed, PMID 15037714.
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Abstract
The authors conducted a randomized, crossover, double-blind, placebo-controlled pilot study of albuterol in nine boys with dystrophinopathies. Primary outcomes were 1) isometric knee extensor and flexor strength; and 2) manual muscle testing (MMT). Isometric knee extensor strength and MMT scores were significantly higher in patients taking albuterol vs placebo. Therefore, 12-week treatment with extended-release albuterol may increase strength in patients with dystrophinopathies. A larger, double-blind, randomized study is necessary to confirm these results.
Medical subject headings
- Adrenergic beta-Agonists
- Albuterol
- Muscular Dystrophy, Duchenne