Cu(I)-catalyzed direct addition and asymmetric addition of terminal alkynes to imines.
basic_science · Level V
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- Record sourced from PubMed, PMID 15067132.
- Also identified by PMC identifier 395979.
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Abstract
A Cu(I)-catalyzed direct addition of alkynes to imines was developed. The process is simple and provides a diverse range of propargylamines in high enantiomeric excess and good yield both in water and in toluene. The absolute configuration of such addition products has been determined by x-ray crystallography.