Interleukin receptor-associated kinase (IRAK-4) deficiency associated with bacterial infections and failure to sustain antibody responses.
case_report · Level V
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- Record sourced from PubMed, PMID 15069404.
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Abstract
We previously described a girl with recurrent episodes of pneumococcal pneumonia with septicemia and other infections,(1) found to have interleukin-1 receptor-associated kinase 4 deficiency (IRAK-4) deficiency.(2) In this report, we show that our patient is unable to sustain antibody responses either to polysaccharide or protein antigens or to a neoantigen-bacteriophage.
Medical subject headings
- Antibodies, Bacterial
- Bacterial Infections
- Phosphotransferases (Alcohol Group Acceptor)