Tip20p prohibits back-fusion of COPII vesicles with the endoplasmic reticulum.
basic_science · Level V
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- Record sourced from PubMed, PMID 15073376.
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Abstract
Directionality in intracellular trafficking is essential to ensure the correct localization of proteins along the secretory pathway. Here, we found evidence for an active mechanism that prohibited back-fusion of de novo-generated vesicles with their donor compartment. Tip20p is a peripheral membrane protein implicated in consumption of COPI vesicles at the endoplasmic reticulum. However, a specific mutant of TIP20 did not interfere with COPII vesicle generation but allowed these vesicles to fuse back to the endoplasmic reticulum, a process that does not occur normally in the cell.
Medical subject headings
- COP-Coated Vesicles
- Carrier Proteins
- Endoplasmic Reticulum
- Glycoproteins
- Membrane Fusion
- Saccharomyces cerevisiae