The hyperleptinemia of obesity-regulator of caloric surpluses.
review · Level V
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Abstract
New evidence suggests that leptin and other anorexigenic agents reduce appetite by inactivating hypothalamic AMP-activated protein kinase (AMPK), thereby increasing malonyl CoA levels. This preview examines AMP biology and its role in malonyl-CoA generation and attempts to integrate its central actions with its peripheral antilipotoxic actions within the context of leptin physiology in obesity.
Medical subject headings
- Energy Intake
- Leptin
- Malonyl Coenzyme A
- Multienzyme Complexes
- Obesity
- Protein Serine-Threonine Kinases