Driven to autoimmunity: the nod mouse.
basic_science · Level V
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- Record sourced from PubMed, PMID 15084253.
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Abstract
In the lymphoid system, T cells respond to space or under-crowding by dividing to maintain their numbers. In this issue of Cell, evidence is provided that this homeostatic proliferation, coupled with excess production of a cytokine, IL-21, is a key factor in susceptibility to autoimmune diabetes.
Medical subject headings
- Diabetes Mellitus, Type 1
- Genetic Predisposition to Disease
- Interleukins
- Mice, Inbred NOD
- T-Lymphocytes