Insig: a significant integrator of nutrient and hormonal signals.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 15085189.
- Also identified by PMC identifier 385410.
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Abstract
Lipogenesis is regulated by sterols and by insulin through the regulated expression and activation of the sterol regulatory element-binding proteins (SREBPs). A new study shows one way in which sterol and insulin regulation can be decoupled. In transgenic mice overexpressing a protein that regulates SREBP activation, lipogenesis is more sensitive to cholesterol and less sensitive to insulin.
Medical subject headings
- Insulin
- Lipids
- Membrane Proteins
- Transcription Factors