Experimental autoimmune hearing loss.
basic_science · Level V
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- Record sourced from PubMed, PMID 15085190.
- Also identified by PMC identifier 385415.
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Abstract
Understanding of autoimmune sensorineural hearing loss (ASNHL) has been hindered by the inaccessibility of the inner ear to biopsy and the lack of workable animal models. A report in this issue of the JCI describes a mouse model of CD4(+) T cell-mediated ASNHL induced by immunization with peptides from the inner ear-specific proteins cochlin and beta-tectorin.
Medical subject headings
- Autoimmune Diseases
- CD4-Positive T-Lymphocytes
- Extracellular Matrix Proteins
- Hearing Loss, Sensorineural
- Membrane Proteins
- Proteins