Investigation of racemisation in peptide synthesis within a micro reactor.
basic_science · Level V
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- Record sourced from PubMed, PMID 15100824.
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Abstract
We demonstrate that peptides derived from alpha-amino acids may be prepared in a micro reactor. The peptides were prepared in 20 min with quantitative conversion, compared to batch reactions which require prolonged reaction times. We illustrate that by using dilute reagent concentrations and short reaction times, less racemisation is observed in micro reactions than in bulk reactions.
Medical subject headings
- Peptides