The aldol reaction of silyl enol ethers within a micro reactor.

Wiles, C; Watts, P; Haswell, S J; Pombo-Villar, E · Lab Chip · 2001

basic_science · Level V

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Abstract

We have demonstrated the use of silyl enol ethers in the aldol reaction within a micro reactor. Quantitative conversion of the silyl enol ether to a beta-hydroxyketone was observed in a 20 min period compared to traditional batch systems, where quantitative yields were only obtained when extended reaction times of 24 h were employed.