The investigation of an equilibrium dependent reaction for the formation of enamines in a microchemical system.

Sands, M; Haswell, S J; Kelly, S M; Skelton, V; Morgan, D O; Styring, P; Warrington, B · Lab Chip · 2001

basic_science · Level V

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Abstract

The paper describes the equilibrium dependant reaction for the formation of enamines in a microchemical system utilising electroosmotic flow (EOF) for fluid mobilisation. The authors have shown that the reaction can be carried out without the presence of a Lewis acid catalyst, in addition the enamine intermediate was synthesised at room temperature using mild solvent conditions. A 42% conversion of cyclohexanone into the enamine has been achieved to date.