Telomerase regulation at the telomere: a binary switch.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 15109487.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Telomerase is known to preferentially elongate the shortest telomeres in a cell. Using an elegant yeast assay, Texeira et al. (2004 [this issue of Cell]) address what aspect of telomerase action is regulated by telomere length: the frequency or the extent of telomere elongation. They show that short telomeres are elongated more frequently than long telomeres, arguing that telomeres switch between two states, one that allows telomere extension and one that does not.
Medical subject headings
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Fungal
- Saccharomyces cerevisiae
- Telomerase
- Telomere