Measurement error of two different techniques for brain atrophy assessment in multiple sclerosis.
cross_sectional · Level IV
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Abstract
The measurement errors associated with two techniques for brain atrophy assessment in multiple sclerosis (MS) were estimated. The measurement error of a semiautomated, nonnormalized technique with partial brain coverage was about twofold higher than that of a fully automated, normalized technique with full brain coverage (Structural Image Evaluation of Normalized Atrophy software [SIENA]). As shown by the analysis of data from a clinical trial of glatiramer acetate, the use of SIENA increases the study power to detect a treatment effect on brain volume changes in MS patients.
Medical subject headings
- Atrophy
- Brain
- Brain Diseases
- Magnetic Resonance Imaging
- Multiple Sclerosis