The diploid genome sequence of Candida albicans.
basic_science · Level V
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- Record sourced from PubMed, PMID 15123810.
- Also identified by PMC identifier 409918.
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Abstract
We present the diploid genome sequence of the fungal pathogen Candida albicans. Because C. albicans has no known haploid or homozygous form, sequencing was performed as a whole-genome shotgun of the heterozygous diploid genome in strain SC5314, a clinical isolate that is the parent of strains widely used for molecular analysis. We developed computational methods to assemble a diploid genome sequence in good agreement with available physical mapping data. We provide a whole-genome description of heterozygosity in the organism. Comparative genomic analyses provide important clues about the evolution of the species and its mechanisms of pathogenesis.
Medical subject headings
- Candida albicans
- Diploidy
- Genome, Fungal