Dysbindin-1 and schizophrenia: from genetics to neuropathology.
editorial · Level V
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- Record sourced from PubMed, PMID 15124015.
- Also identified by PMC identifier 398436.
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Abstract
The gene encoding dysbindin-1 has recently been implicated in susceptibility to schizophrenia. In this issue of the JCI, Talbot et al. show that, contrary to expectations, dysbindin-1 is located presynaptically in glutamatergic neurons and is reduced at these locations in schizophrenia. Further studies of dysbindin-1 and the proteins with which it interacts can be expected to throw light on the pathogenesis of schizophrenia.
Medical subject headings
- Carrier Proteins
- Membrane Transport Proteins
- Neurons
- Schizophrenia
- Vesicular Transport Proteins