Depletion of methionine aminopeptidase 2 does not alter cell response to fumagillin or bengamides.
basic_science · Level V
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Abstract
Inhibition of endothelial cell growth by fumagillin has been assumed to be mediated by inhibition of the molecular target methionine aminopeptidase 2 (MetAp2). New data show that depletion of MetAp2 by siRNA does not inhibit endothelial cell growth. Moreover, MetAp2-depleted endothelial cells remain responsive to inhibition by either fumagillin or a newly identified MetAp2 enzyme inhibitor. These data suggest that MetAp2 function is not required for endothelial cell proliferation.
Medical subject headings
- Aminopeptidases
- Azepines
- Fatty Acids, Unsaturated
- Metalloendopeptidases