Progressive beta cell failure in type 2 diabetes mellitus of youth.
case_report · Level V
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- Record sourced from PubMed, PMID 15127006.
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Abstract
The pathophysiology of type 2 diabetes mellitus (T2DM) involves insulin resistance and insulin deficiency. We report the progression in insulin sensitivity and secretion over a 6-year period in an adolescent with T2DM. This report further demonstrates that the earliest abnormality in youth T2DM is insulin resistance followed by progressive beta-cell failure.
Medical subject headings
- Diabetes Mellitus, Type 2
- Islets of Langerhans