Desipramine potentiates spinal antinociception by 5-hydroxytryptamine, morphine and adenosine.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 1513600.
- Also identified by DOI 10.1016/0304-3959(92)90118-U.
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Abstract
The effects of pretreatment with desipramine, a selective noradrenaline (NA) uptake blocker, on spinal antinociception by 5-hydroxytryptamine (5-HT), morphine and an adenosine analog (NECA) in the rat hot-plate test were examined to determine if endogenous NA is involved in the spinal action of these agents. Desipramine, 25 mg/kg, had no significant intrinsic effect in the hot-plate test but potentiated spinal antinociception by NA and 5-HT. Potentiation was more prominent at higher doses of NA and 5-HT. Desipramine also enhanced the action of morphine and NECA, but, in these instances, the greatest enhancement occurred at lower doses. These results, in conjunction with others, suggest that 5-HT releases NA from the spinal cord while morphine and NECA interact synergistically with endogenously released NA.
Medical subject headings
- Adenosine
- Desipramine
- Morphine
- Nociceptors
- Serotonin
- Spinal Cord