Oligomeric catechins: an enabling synthetic strategy by orthogonal activation and C(8) protection.

Ohmori, Ken; Ushimaru, Naoko; Suzuki, Keisuke · Proc Natl Acad Sci U S A · 2004

basic_science · Level V

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Abstract

Controlled formation of oligomeric catechins has become possible by an orthogonal synthetic strategy. Bromo-capping of the C(8) position of the flavan skeleton enabled the equimolar coupling of electrophilic and nucleophilic catechin derivatives, enabling an efficient synthetic strategy to complex catechin oligomers.

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